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Melaka virus
Melaka virus (MELV) is a novel bat-borne virus of the Pteropine orthoreovirus species. It was first isolated in a human in Melaka, Malaysia in 2006. A bat reservoir was suspected because traceback analysis revealed that the patient had been exposed to a bat prior to the onset of infection. Melaka virus causes a non-fatal respiratory tract illness in humans.〔Chua KB, Crameri G, Hyatt A,Yu M, Tompang MR, Rosli J, McEachern J, Crameri S, Kumarasamy V, Eaton BT, Wang LF. 2007. A previously unknown reovirus of bat origin is associated with an acute respiratory disease in humans. Proceedings of the National Academy of Sciences of the United States of America. 104 (27): 11424-11429.〕〔Chua KB, Voon K, Yu M, Keniscope C, Rasid KA, Wang LF. 2011. Investigation of a potential zoonotic transmission of orthoreovirus associated with acute influenza-like illness in an adult patient. PLoS ONE. 6(10): e25434.〕
== Virology ==
Melaka virus is a nonenveloped, segmented, double-stranded RNA virus. Having a segmented genome facilitates reassortment. Melaka is a fusogenic virus which enhances virulence in its ability to carry out cell-cell fusion.〔Day JM. The diversity of the orthoreoviruses: molecular taxonomy and phylogenetic divides. Infect Genet Evol. 2009;9:390–400. DOI PubMed〕〔Knipe DM, Howley PM, eds. Orthoreoviruses and their replication. Fields virology, 5th ed. Philadelphia: Lippincott Williams & Wilkins; 2007. p. 1854–915.〕
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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